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What do solid tumours, certain congenital types of deafness and rheumatoid arthritis have in common? A deregulation in the function of the protein KIAA1199! In a study published in Nature communications, a team of researchers - lead by Pr Alain Chariot - from the University of Liège reveal the link between this protein and a receptor known as EGFR, a key protagonist in tumour development and progression. A link that could be of importance for these human diseases...
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(1) Kateryna Shostak, Xin Zhang, Pascale Hubert, Serkan Ismail Göktuna, Zheshen Jiang, Iva Klevernic, Julien Hildebrand, Patrick Roncarati, Benoit Hennuy, Aurélie Ladang, Joan Somja, André Gothot, Pierre Close, Philippe Delvenne & Alain Chariot. NF-κB-induced KIAA1199 promotes survival through EGFR signalling. Nature communications| 5:5232 | DOI: 10.1038/ncomms6232 | |
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![EGFR resume]( "EGFR resume.") |
