Should caution be exercised with regard to the use of cardiac magnetic resonance?
Researchers at the GIGA-Cardiovascular Sciences laboratory of the University of Liege are advising caution with regard to repeated use of cardiac magnetic resonance, a commonly-used radiological examination. They showed that this examination induced signals that mimic DNA double-strand breaks in T lymphocytes, but that this effect, which is slight and temporary, disappears after one year. However, they still need to demonstrate the presence of such DNA double-strand breaks. If their results are confirmed, they will suggest a prudent approach to the use of this technology.
The double-strand breaks signals return to baseline levels after one year
So what were the results? Professor Lancellotti and his colleagues were able to observe a slight but significant increase in the level of gamma-H2AX after 2 days and 1 month post-CMR. This DNA damage did not, however, induce the apoptosis of the T lymphocytes and activation of the T lymphocytes was not observed.
1 Biological Effects of Cardiac Magnetic Resonance on Human Blood Cells, Circ Cardiovascular Imaging 2015; 8:e003697