Regenerating cells in the inner ear
The hair cells present in the auditory portion of the inner ear – the organ of Corti in the cochlea - are indispensable to the transmission of sound to our brain. Unfortunately, when these cells are destroyed they are not replaced resulting in hearing impairments or even deafness. Brigitte Malgrange and her team are working on an important line of research involving the regeneration of hair cells in the cochlea: they have discovered that when the expression or function of Ephrin-B2 protein is inhibited, the cochlear supporting cells transdifferentiate into hair cells. This enabled them to create new hair cells at the right place in the organ of Corti.
Hair cells and sensorineural deafness
According to the type of structure affected within the ear, there are two kinds of deafness, conductive or sensorineural. Conductive deafness more particularly concerns the external or middle ear while sensorineural deafness is caused by damage to the inner ear or the auditive nerve. Professor Brigitte Malgrange’s team have therefore focused their attention on these structures and on sensorineural deafness in particular. Professor Malgrange is the head of the Developmental Neurobiology Research Unit of the GIGA. “The objective of our research is to better understand the development of the auditory portion of the cochlea, the hearing organ”, explains Brigitte Malgrange. “Inside the cochlea there is an organ called organ of Corti which is the sensory element involved in hearing”. The organ of Corti is composed of two main types of cells: supporting cells and hair cells. “The hair cells directly transmit auditory information to the neurones to enable this information to reach the brain”, continues the researcher. The hair cells are therefore of capital importance for sound perception. When these cells are destroyed, they do not regenerate and this leads to sensorineural deafness. In the context of his PhD, Jean Defourny studied how these cells are generated. “Understanding the underlying mechanisms involved in the development of the hair cells should enable us to use these same mechanisms to combat deafness”, continues Brigitte Malgrange.